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To date, the exact binding web-site of MIF to CD74 isn't clear, but small molecules and mutations concentrating on the tautomerase Lively site pocket are proven to interfere Together with the binding of MIF to CD74 [forty four]. Curiously, admirer et al. manufactured a single cysteine mutant of MIF (MIFN110C) that covalently locks MIF into a trimer
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